Cycloheximide stimulates suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes via the extracellular signal-regulated kinase pathway

► Cycloheximide activates adipocyte SOCS-3 gene expression. ► Cycloheximide selectively affects gene expression of other SOCS family members. ► The MEK1/ERK-mediated pathway is necessary for the effect of cycloheximide. ► The effect of cycloheximide on SOCS-3 gene expression varies with the cell type.