Rosiglitazone, a PPAR-γ agonist, protects against striatal dopaminergic neurodegeneration induced by 6-OHDA lesions in the substantia nigra of rats

► Intranigral 6-OHDA injection induced striatal TH fiber loss. ► COX-2 involved in 6-OHDA-mediated TH fiber degeneration. ► PPARγ agonist prevents 6-OHDA-induced neuronal damage.