Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis

► Administration of TAA for 9 weeks led to a serious liver necrosis and collagen deposition. ► GSPE diminishes TAA-induced mRNA expression of TGF-β1, α-SMA and α1-(I)-collagen. ► GSPE suppresses the collagen deposition and the activated HSCs induced by TAA.