Rat hyperactivity by bisphenol A, but not by its derivatives, 3-hydroxybisphenol A or bisphenol A 3,4-quinone

► Molecular species involved in bisphenol A-caused hyperactivity was examined. ► The parent chemical increased spontaneous motor activity 1.3 fold. ► Its metabolites had no effects on the motor activity. ► The parent compound resided 7% in the brain. The amount of the metabolites was not determined.