Effect of brominated flame retardant BDE-47 on androgen production of adult rat Leydig cells

► We explored the effect of BDE-47 on androgen production of Leydig cells. ► Low dose BDE-47 increased testosterone at a dose-dependent manner. ► StAR, cAMP and P450Scc might be its potential action sites. ► This is the first report on effects of low dose BDE-47 on testosterone production in ALCs in vitro.