کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860923 | 1562642 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of the dermal and ocular irritation potential of multi-walled carbon nanotubes by using in vitro and in vivo methods
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
In vitro and in vivo studies on ocular and dermal irritation were carried out with two different sizes of multi-walled carbon nanotubes (MWCNT). The results of acute eye irritation toxicity studies with two different sizes of MWCNT in rabbits demonstrated reversible conjunctival redness and discharge and exhibited minimal concern while acute dermal irritation studies indicated that MWCNT of two sizes were non-irritant to the skin of rabbits. Both the sizes of MWCNT revealed non-irritant result in HE-CAM test. In vitro skin (EPISKIN) irritation studies revealed that two sizes of MWCNT are non-irritant to skin. In conclusion this work purports, the future of alternative research lies in the validation of the methodology for nanomaterials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 191, Issues 2â3, 15 December 2009, Pages 268-274
Journal: Toxicology Letters - Volume 191, Issues 2â3, 15 December 2009, Pages 268-274
نویسندگان
A. Sairam Kishore, P. Surekha, P. Balakrishna Murthy,