کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5861371 | 1133760 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bisphenol A and its analogs induce morphological and biochemical alterations in human peripheral blood mononuclear cells (in vitro study)
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کلمات کلیدی
BPAPNACFSC2,4,5-TCPSSCPCP6-carboxy-2′,7′-dichlorodihydrofluorescein diacetatehpfBPFPBMCsBPAFBPS2,4,5-Trichlorophenol - 2،4،5-تری کلروفنلcis-parinaric acid - اسید cis-parinaricBisphenols - بیسفنولBisphenol AF - بیسفنول AFBisphenol F - بیسفنول Fbisphenol S - بیسفنول SBisphenol A - بیسفنول ای، بیسفنول AMorphological alterations - تغییرات مورفولوژیکیCell viability - زنده ماندن سلولperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیLipid peroxidation - پراکسیداسیون لیپیدPentachlorophenol - پنتا کلروفنلReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Few studies have addressed the cellular effects of bisphenol S (BPS) and bisphenol AF (BPAF) on cells, and no study has been conducted to analyze the mechanism of action of bisphenols in blood cells. In this study, the effect of bisphenol A (BPA), bisphenol F (BPF), BPS and BPAF on human peripheral blood mononuclear cells (PBMCs) was analyzed. It was shown that BPA, BPF and BPAF in particular, decreased cell viability, which was associated with depletion of intracellular ATP level and alterations in PBMCs size and granulation. Bisphenols enhanced ROS (including OH) formation, which led to damage to lipids and proteins in PBMCs. The most significant alterations in ROS level were induced by BPF, and particularly BPAF. Moreover, it was shown that BPAF most strongly provoked lipid peroxidation, while BPA and BPS caused the greatest damage to proteins. It may be concluded that BPA and its analogs were capable of inducing oxidative stress and damage in PBMCs in the concentrations ranging from 0.06 to 0.5 μM (0.02-0.1 μg/ml), which may be present in human blood as a result of environmental exposure. Although, most of bisphenols studied decreased cell viability, size and ATP level at higher concentrations, BPAF exhibited its cytotoxic potential at low concentrations ranging from 0.3 to 3 μM (0.1-1.0 μg/ml) that may correspond to concentrations in humans following occupational exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 29, Issue 7, October 2015, Pages 1464-1472
Journal: Toxicology in Vitro - Volume 29, Issue 7, October 2015, Pages 1464-1472
نویسندگان
Jaromir MichaÅowicz, Katarzyna Mokra, Agata BÄ
k,