Cell cycle arrest, extracellular matrix changes and intrinsic apoptosis in human melanoma cells are induced by Boron Neutron Capture Therapy

► BNCT induced few morphological alterations in normal melanocytes. ► Melanoma after BNCT showed early cell death and cell cycle arrest. ► Normal melanocytes had no significant differences due to BNCT treatment. ► Cell cycle arrest, ECM changes and intrinsic apoptosis are signaling pathways involved in human melanoma treatment by BNCT.