Abamectin affects the bioenergetics of liver mitochondria: A potential mechanism of hepatotoxicity

► Abamectin causes hepatotoxicity in animals. ► We study the effects of abamectin on the bioenergetics of liver mitochondria. ► Abamectin caused dose-dependent inhibition of the mitochondrial ATP synthesis. ► Abamectin inhibits the FoF1-ATPase and adenine nucleotide translocator activities. ► Impairment of mitochondrial bioenergetics could be involved in abamectin toxicity.