The role of mitochondria and biotransformation in abamectin-induced cytotoxicity in isolated rat hepatocytes

► ABA is cytotoxic to rat isolated hepatocytes at concentrations from 25-100 μM. ► ABA affects the mitochondrial bioenergetics in rat isolated hepatocytes. ► ABA treatment alters intracellular Ca2+ homeostasis. ► ABA caused cellular death by necrosis. ► Biotransformation of ABA reduces its toxicity.