In vitro toxicity of camalexin derivatives in human cancer and non-cancer cells

► Cytotoxicity of indole phytoalexins was studied in human cancer and non-cancer cells. ► Significant cytotoxicity was achieved for benzocamalexin (BC) in cancer cells. ► It downregulated α, α1 and β5-tubulin expression and caused G2 cell cycle arrest. ► BC also induced apoptosis which was accompanied by increasing Bax/Bcl-2 ratio.