In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

► Chinese hamster lung fibroblast cells exposed to nano-TiO2 demonstrated cyto- and genotoxic responses. ► There is a correlation between cyto- and geno-toxicological endpoints using different TiO2 samples. ► The treated cells demonstrated the intracellular ROS generation, a common toxicity mechanism. ► The polyacrylate coated nano-TiO2 decreased the cyto- and genotoxicity responses.