Fragrance chemicals lyral and lilial decrease viability of HaCat cells' by increasing free radical production and lowering intracellular ATP level: Protection by antioxidants

► Fragrant chemicals lyral/lilial decreased viability of HaCat cells. ► lyral/lilial-decreased ATP level and increased: ROS level and LDH release in HaCat cells. ► Lyral/lilial inhibited liver sub-mitochondrial particles complexes I and II activities of respiratory chain. ► Antioxidants restored control ROS level; lipoic acid protected the viability of lilial and lyral treated Hacat cells. ► Lyral and lilila are mitochondriotoxin with direct and indirect effect on HaCat cells.