کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5862859 | 1133784 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Extracellular and intracellular anti-mutagenic effects of bile pigments in the Salmonella typhimurium reverse mutation assay
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کلمات کلیدی
PhIPBRDTBilirubin ditaurateTA98Frame-shift2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine - 2-amino-1-methyl-6-phenylimidazo [4،5-b] pyridineAFB1 - AFB 1t-BOOH - T-BOOHAflatoxin B1 - آفلاتوکسین B1unconjugated bilirubin - بیلی روبین غیر مرتبطBiliverdin - بیلیاردینBilirubin - بیلیروبینSalmonella Typhimurium - سالمونلا تیفی موریومCancer - سرطانTertiary butyl hydroperoxide - هیدروپراکسید استیل بوتیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Extracellular and intracellular anti-mutagenic effects of bile pigments in the Salmonella typhimurium reverse mutation assay Extracellular and intracellular anti-mutagenic effects of bile pigments in the Salmonella typhimurium reverse mutation assay](/preview/png/5862859.png)
چکیده انگلیسی
In vitro anti-genotoxic properties of bile pigments have been explored and confirmed recently. Despite these reports mechanisms to explain DNA protection by endogenous bile pigments remain unclear. Surprisingly, the quantification of cellular pigment absorption which could represent a fundamental prerequisite for intracellular (e.g., anti-mutagenic) effects, has not been explored. Therefore, we aimed to measure the amounts of un-/conjugated bilirubin as well as biliverdin absorbed into colonies of Salmonella typhimurium, utilising HPLC analyses, and to observe whether intracellular compound concentrations could predict anti-genotoxic effects. HPLC analyses confirmed that bacterial bile pigment absorption was concentration-dependent. Plate bile pigment concentrations were inversely associated with genotoxicity of all tested mutagens, irrespective of strain and test conditions. However, protection against frame-shift mutation in strain TA98 most strongly depended on the bacterial absorption of bilirubin and biliverdin, which indicates that bile pigments can protect by intercepting mutations extracellularly and specifically inhibit frame-shift mutations intracellularly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 27, Issue 1, February 2013, Pages 433-437
Journal: Toxicology in Vitro - Volume 27, Issue 1, February 2013, Pages 433-437
نویسندگان
C. Mölzer, H. Huber, K. Diem, M. Wallner, A.C. Bulmer, K.-H. Wagner,