Oxidative stress in human lymphocytes treated with fatty acid mixture: Role of carotenoid astaxanthin

► We evaluated the oxidative stress in human lymphocytes induced by a FA mixture and the protective role of ASTA. ► FA mixture increased ROS production, oxidative stress and proliferative capacity of B-lymphocytes. ► ASTA decreased the proliferative capacity of cells not by reducing intracellular calcium concentration. ► ASTA partially prevent oxidative stress induced by FA by blenching/quenching free radical production.