Nerolidol effects on mitochondrial and cellular energetics

► Toxicological evaluation of a sesquiterpene commonly present in plant essential oils. ► Nerolidol interfere with the mitochondrial membrane in an unspecific way. ► Nerolidol inhibit F0F1-ATPsynthase in a concentration dependent manner. ► Hepatic cell cytotoxicity a putative effect from a decrease in ATP/ADP levels.