کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5863146 | 1133806 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective Assessment of the toxicity of silver nanoparticles in vitro: A mitochondrial perspective](/preview/png/5863146.png)
The major toxicological concern associated with nanomaterials is the fact that some manufactured nanomaterials are redox active, and some particles transport across cell membranes, especially into mitochondria. Thus, evaluation of their toxicity upon acute exposure is essential. In this work, we evaluated the toxicity of silver nanoparticles (40 and 80Â nm) and their effects in rat liver mitochondria bioenergetics.Wistar rat liver mitochondria demonstrate alterations in respiration and membrane potential capacities in the presence of either 40 or 80Â nm silver nanoparticles. Our data demonstrated a statistically significant decrease in mitochondrial membrane potential, ADP-induced depolarization, and respiratory control ratio (RCR) upon exposure to silver nanoparticles.Our results show that silver nanoparticles cause impairment of mitochondrial function, due mainly to alterations of mitochondrial membrane permeability. This results in an uncoupling effect on the oxidative phosphorylation system. Thus, mitochondrial toxicity may have a central role in the toxicity resulting from exposure to silver nanoparticles.
Journal: Toxicology in Vitro - Volume 25, Issue 3, April 2011, Pages 664-670