Original Full Length ArticleOsteoporosis risk and bone mineral density levels in patients with Parkinson's disease: A meta-analysis

IntroductionParkinson's disease (PD) and osteoporosis are common diseases which affect a substantial portion of the elderly population. Accumulating evidence supports that PD patients have a high risk for osteoporosis in recent years. The purpose of the present study is to perform a meta-analysis on the risk of osteoporosis and bone mineral density (BMD) levels in PD patients.MethodsWe searched all articles indexed in Medline, SciVerse Scopus and Cochrane Library published up to January 2012 concerning the association between PD and risk of osteoporosis or BMD levels. In total, 15 studies were included in the meta-analysis.ResultsThe results indicated that PD patients are at higher risk for osteoporosis (summary OR = 1.18, 95% CI = [1.09, 1.27]) than healthy controls. The gender subgroup analysis suggested that PD male patients have a higher risk for osteoporosis than female patients (female patients: summary OR = 1.16, 95% CI = [1.07, 1.26]; male patients: summary OR = 2.44, 95% CI = [1.37, 4.34]). Further meta-analysis showed that PD patients have a lower hip, lumbar spine and femoral neck BMD than healthy controls. The gender subgroup analysis found a lower BMD in PD female patients than controls, while no obvious difference was observed in PD male patients and controls.ConclusionsThis meta-analysis suggested that PD patients are at higher risk for osteoporosis and have lower BMD levels than healthy controls overall.

► Increasing evidence supports that PD patients have a high risk for osteoporosis. ► We performed a meta-analysis on osteoporosis risk and BMD levels in PD patients. ► PD patients are at higher risk for osteoporosis than healthy controls. ► PD patients have lower BMD levels than controls overall.