Effect of high phosphorus diet on tooth microstructure of rodent incisors

► In this study we examine the chronic effect of high phosphorus diet on the mandibular incisor microstructure in degus using macroscopic observation, histopathological examination, transmission and scanning electron microscopy. ► Enamel and dentin development is disturbed under high phosphorus diet and improper calcium to phosphor ratio. ► Disturbed mineral metabolism resulted in enamel depigmentation, enamel hypoplasia, enamel pitting and altered dentin. ► More attention should be focused on dietary phosphorus content when facing altered tooth structure in young patients with deciduous or permanent dentition.