کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5891970 1153283 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original Full Length ArticlePhysical activity, body mass index and bone mineral density-associations in a prospective population-based cohort of women and men: The Canadian Multicentre Osteoporosis Study (CaMos)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Original Full Length ArticlePhysical activity, body mass index and bone mineral density-associations in a prospective population-based cohort of women and men: The Canadian Multicentre Osteoporosis Study (CaMos)
چکیده انگلیسی

BackgroundPhysical activity (PA) is an important modifiable risk factor for both bone mineral density (BMD) and body mass index (BMI). However, BMI is itself strongly predictive of BMD. Our aim was to determine the association between PA and BMD, with consideration of BMI as a potential mediating factor.MethodsThe Canadian Multicentre Osteoporosis Study (CaMos) is a population-based prospective cohort study of Canadian women and men. PA was determined from interviewer-administered questionnaires at baseline and Year 5 and summarized as daily energy expenditure in total metabolic equivalents of the task multiplied by minutes/day (MET*m/d). Height, weight, and total hip and lumbar spine BMD were measured at baseline and Year 5. General linear models assessed relationships between PA and BMD, both cross-sectionally (baseline PA with baseline BMD) and longitudinally (average PA and change in PA with change in BMD). BMI was considered as a mediating factor. Potential confounders included age, center, education, caffeine intake, alcohol exposure, smoking history, history of weight-cycling, age at menarche, past use of oral contraceptives, history of > 3 months missed menstruation, menopausal status, and antiresorptive use, as relevant.ResultsThe study included 2855 men and 6442 women. PA was inversely associated with BMI at baseline, and an increase in PA between baseline and Year 5 was associated with a decrease in BMI, with 0.41 (95% CI: 0.22, 0.60) kg/m2 loss per 1000 MET*m/d increase (in men) and 0.40 (95% CI: 0.23, 0.57) kg/m2 loss per 1000 MET*m/d increase (in women). BMI was strongly associated with BMD, both cross-sectionally and longitudinally. However, increased PA was associated with a small increase in total hip BMD, 0.004 (95% CI: 0.000-0.008) g/cm2 per 1000 MET*m/d (in men) and 0.003 (95% CI: 0.000-0.007) g/cm2 per 1000 MET*m/d (in women). Average PA was associated with an increase in lumbar spine BMD in women, but not in men; it was not associated with change in total hip BMD in either sex.ConclusionIncreased PA is associated with an increase in BMD and a concomitant decrease in BMI. These findings suggest that population-level interventions to increase PA would favorably impact bone and other health outcomes.

► Walking-a cohort mean of 30 minutes per day-was associated with increased hip BMD. ► Men & women had similar physical activity; men did more strenuous exercise and work. ► Five year increases in physical activity relate to increased BMD and decreased BMI".

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 50, Issue 1, January 2012, Pages 401-408
نویسندگان
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