Safety of bisphosphonates

►The association between oral bisphosphonate and esophageal cancer is controversial. ►Atypical femur fractures are very rare but bisphosphonate use is a risk factor. ►ONJ is a complication strongly related to frequent IV bisphosphonate use. ►Atrial fibrillation is not a concern in oral bisphosphonate users. ►Atrial fibrillation is not a concern in oral bisphosphonate users. ►The optimum duration of bisphosphonate treatment is not known.