کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5892950 1568239 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insights into sensory hair cell regeneration from the zebrafish lateral line
ترجمه فارسی عنوان
نگاهی به بازسازی سلول های موی حسی از خط جانبی زبرا ماهی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

Loss of mechanosensory hair cells in the inner ear leads to loss of hearing. In humans this results in permanent deafness, as mammals are largely unable to regenerate hair cells. In contrast, zebrafish robustly regenerate hair cells in the sensory lateral line and ear and recent gene expression and time-lapse analyses of cell behaviors at the single cell level have greatly advanced our understanding of the mechanisms responsible for hair cell regeneration. In the lateral line, hair cell regeneration is controlled via dynamic interactions between Notch and Wnt/β-catenin signaling, and likely also between Fgf and the retinoic acid signaling pathways. Less is known about what initiates regeneration and we discuss potential pathways that may trigger proliferation after hair cell damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 40, October 2016, Pages 32-40
نویسندگان
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