کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5893369 | 1568253 | 2014 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Aging: not all DNA damage is equal Aging: not all DNA damage is equal](/preview/png/5893369.png)
Recent advances have identified accumulation of DNA damage as a major driver of aging. However, there are numerous kinds of DNA lesions each with their own characteristics and cellular outcome, which highly depends on cellular context: proliferation (cell cycle), differentiation, propensity for survival/death, cell condition and systemic hormonal and immunological parameters. In addition, DNA damage is strongly influenced by cellular metabolism, anti-oxidant status and exogenous factors, consistent with the multi-factorial nature of aging. Notably, DNA lesions interfering with replication have very different outcomes compared to transcription. These considerations provide a conceptual framework in which different types of DNA damage and their setting contribute to the aging process in differential manners.
Journal: Current Opinion in Genetics & Development - Volume 26, June 2014, Pages 124-130