کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5893454 | 1568252 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Intergenic lncRNAs and the evolution of gene expression Intergenic lncRNAs and the evolution of gene expression](/preview/png/5893454.png)
Eukaryote genomes encode a surprisingly large number of noncoding transcripts. Around two-thirds of human transcribed loci do not encode protein, and many are intergenic and produce long (>200 nucleotides) noncoding RNAs (lncRNAs).Extensive analyses using comparative genomics and transcriptomics approaches have established that lncRNA sequence and transcription tend to turn over rapidly during evolution.Our appreciation of the biological roles of lncRNAs, based only on a handful of transcripts with well-characterized functions, is that lncRNAs have diverse roles in regulating gene expression.These proposed roles together with their rapid rates of evolution suggest that lncRNAs could contribute to the divergent expression patterns observed among species and potentially to the origin of new traits.
Journal: Current Opinion in Genetics & Development - Volume 27, August 2014, Pages 48-53