کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5893513 1153908 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chromatin organization: form to function
ترجمه فارسی عنوان
سازمان کروماتین: فرم برای عملکرد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional properties. Microscopy and chromatin conformation capture techniques have shown that the 3D structure of chromosomes is constrained by nuclear features and functional links between different parts of chromatin. These results provide insights about the 3D and domain organization of the genome and their connection to gene regulation and other nuclear functions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 23, Issue 2, April 2013, Pages 185–190