کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5893543 1568254 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genome regulation at the peripheral zone: lamina associated domains in development and disease
ترجمه فارسی عنوان
مقررات ژنوم در ناحیه پیرامونی: دامنه های مرتبط با لامین در توسعه و بیماری
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی
The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and overall three-dimensional architecture of the genome. However, the mechanisms of such organization at the 'peripheral zone' and the functional significance of these associations are poorly understood. The role these domains play in development and disease is an active and exciting area of research, expanding our knowledge of how the three-dimensional (3D) genome is regulated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 25, April 2014, Pages 50-61
نویسندگان
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