کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5893593 1153912 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells
چکیده انگلیسی

The human body is formed by trillions of individual cells. These cells work together with remarkable precision, first forming an adult organism out of a single fertilized egg, and then keeping the organism alive and functional for decades. To achieve this precision, one would assume that each individual cell reacts in a reliable, reproducible way to a given input, faithfully executing the required task. However, a growing number of studies investigating cellular processes on the level of single cells revealed large heterogeneity even among genetically identical cells of the same cell type. Here we discuss the sources of heterogeneity in mammalian systems; how cells ensure reliable processing of information despite fluctuations in their molecular components; and what could be the benefit of cell-to-cell variability for mammalian cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 21, Issue 6, December 2011, Pages 753-758
نویسندگان
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