Genomes in the clinic: the Gustave Roussy Cancer Center experience

The extensive molecular characterization of tumors with high throughput technologies has led to the segmentation of different tumors into very small molecularly defined subgroups. Many ongoing clinical trials are conducted only when specific molecular alterations are identified in tumor samples. In this review, we will describe the implementation of genome analysis in the clinical setting as it has expanded over the last four years in our Precision Medicine Program. This manuscript will also highlight the main limitations and challenges related to the development of broader and deeper genome analysis.