کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5893641 1153918 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Towards an understanding of the regulatory mechanisms of totipotency
ترجمه فارسی عنوان
به درک از مکانیزم های نظارتی تاکتیکی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

The 21st century started with an important discovery that a pluripotent stem cell can be induced from differentiated cells by 'simply' introducing a few transcription factors. Because pluripotent embryonic stem cells can be stably maintained in culture and also induced, the mechanisms as to how cells maintain and acquire pluripotency have been extensively interrogated. In contrast, how cells maintain or acquire totipotency and the cell potency that exists in the zygote are still poorly understood. To address this question, it is necessary to capture the features that reside in totipotent cells. Here, we review recent results, which shed light on the unique epigenetic state in totipotent cells, and discuss how totipotency is regulated before finding its way towards pluripotency.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 23, Issue 5, October 2013, Pages 512-518
نویسندگان
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