کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5893660 1153918 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcription factor-induced enhancer modulations during cell fate conversions
ترجمه فارسی عنوان
مدولاسیون تقویت کننده ناشی از فاکتور رونویسی در هنگام تبدیل سلول های سرطانی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی
The activity of transcription factors (TFs) has empowered the reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) and alternative lineages. Elucidation of the molecular mechanisms underpinning these processes has expanded our understanding of how novel gene expression programs become activated while old ones are silenced [1-3]. How TFs modify chromatin and activate requisite enzymes during these processes has recently been discussed in several excellent reviews [4-6]. Here we discuss the questions of how ectopically expressed TFs access chromatin to modulate enhancers and establish a novel transcriptome during cell reprogramming, lineage conversions and differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 23, Issue 5, October 2013, Pages 562-567
نویسندگان
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