کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5893723 1153920 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis
ترجمه فارسی عنوان
بررسی ارتباط ژنوم فنوتیپهای هماتولوژیک: یک پنجره به خون هموگلوبین انسان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی
The study of human hematopoiesis is often limited by the inability to manipulate this process in vivo and differences that exist between humans and commonly employed model organisms. However, human genetics provides a way to gain insight into natural variation in a variety of hematologic phenotypes and creates an opportunity to better understand hematopoiesis. In this review, we discuss how genome-wide association studies are revealing common genetic variation that is associated with hematologic traits and diseases. We discuss how the resulting insight from these studies promises to increase our understanding of human hematopoiesis and outline the challenges that lay ahead in this field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 23, Issue 3, June 2013, Pages 339-344
نویسندگان
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