کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5896773 | 1568735 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer
ترجمه فارسی عنوان
سطح سرمی آدیپوسیتووکین اومانین-1 در بیماران مبتلا به سرطان سلولی کلیه
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کلمات کلیدی
EGFROmentin-1WHRRCCVHLHDL-CeNOSLDL-CCSSRFSDBPSBPAMPKFBGSirt1CREPI3KPCA - PCAAdipokine - آدپیکینvon Hippel-Lindau - از Hippel-LindauRecurrence free survival - بقای آزاد بودن مجددCancer-specific survival - بقای خاص سرطانPearson correlation analysis - تجزیه و تحلیل همبستگی پیرسونtriacylglycerol - تری آسیل گلیسرول Enzyme-linked immunosorbent assay - تست الیزاELISA - تست الیزاstandard error - خطای استانداردRenal cell cancer - سرطان سلول کلیهendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالbody mass index - شاخص توده بدنBMI - شاخص توده بدنیconfidence interval - فاصله اطمینانphosphoinositide 3-kinase - فسفینوزیتید 3-کینازdiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکfasting blood glucose - قند خون ناشتاLow density lipoprotein-cholesterol - لیپوپروتئین و کلسترول پایین چگالیHigh density lipoprotein-cholesterol - لیپوپروتئین-کلسترول چگالی بالاObesity - مرض چاقیestimated glomerular filtration rate - میزان تصفیه گلومرولی برآورد شده استWaist to hip ratio - نسبت دور کمر به باسنodds ratio - نسبت شانس هاadenosine monophosphate-activated protein kinase - پروتئین کیناز فعال شده با آدنوزین مونوفسفاتcreatinine - کراتینینtotal cholesterol - کلسترول تام
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Renal cell carcinoma (RCC) is the fifth most common cancer worldwide, and becomes one of the leading causes of genitourinary cancer-related death in both males and females. Genetic alternations, alcohol consumption, occupationally harmful exposure and even obesity are well-established risk factors of RCC. Omentin-1 is a plasma adipokine synthesized in visceral adipose tissue, and its circulating serum concentration alters not only in conditions associated with insulin resistance such as Polycystic Ovary Syndrome (PCOS), but also in colorectal cancer and prostate cancer. To our best knowledge, the relationship between omentin-1 and RCC has not been clarified previously. Thus, we evaluated serum omentin-1 levels in RCC patients in the current matched case-control study. Forty-one patients newly diagnosed with RCC and forty-two healthy controls confirmed by the comprehensive medical examination were assessed. The omentin-1 concentrations were determined via utilizing enzyme-linked immunosorbent assays (ELISA) in the paired groups, in which the patients and healthy controls had no statistically significant differences in gender, age, systolic blood pressure (SBP), diastolic blood pressure (DBP), waist-hip ratio (WHR), estimate glomerular filtration rate (eGFR), body-mass index (BMI) and biochemical parameters. The omentin-1 levels in healthy people were 9.86 ± 1.44 ng/mL and the circulating omentin-1 levels were dramatically decreased to 3.62 ± 0.76 ng/mL in RCC patients (p < 0.001). Besides, we revealed a negative correlation between omentin-1 with WHR (r = â0.261, p = 0.017) and BMI (r = â0.310, p = 0.004), further indicating BMI was the main influential factor on omentin-1 levels (p = 0.0091). Follow-up studies would be conducted to establish the concrete mechanisms underlying the altered circulating levels of omentin-1 and elucidate the interaction between “RCC complex system” and adipose tissues, which may together provide promising and novel pharmacological insights for RCC theragnosis in the near future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 77, January 2016, Pages 50-55
Journal: Cytokine - Volume 77, January 2016, Pages 50-55
نویسندگان
Xu-Dong Shen, Li Zhang, Hong Che, Yang-Yang Zhang, Cheng Yang, Jun Zhou, Chao-Zhao Liang,