Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines

► Citrullination is a cytokine-specific phenomenon. ► Citrullinated TNF-α is less potent to stimulate chemokine production in vitro. ► Citrullinated TNF-α retains its capacity to induce apoptosis/necrosis. ► Binding of TNF-α to the drug Infliximab is not influenced by citrullination. ► TNF-α and [Cit]TNF-α are equally potent to attract neutrophils in vivo.