کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5897692 | 1155274 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between an interleukin 1 receptor, type I promoter polymorphism and self-reported attentional function in women with breast cancer
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کلمات کلیدی
SCQGMMBLRTKPSAFIBICMAFDNA - DNA یا اسید دزوکسی ریبونوکلئیکdeoxyribonucleic acid - اسید deoxyribonucleicinflammation - التهاب( توروم) AIMS - اهدافAttention - توجهCNS - دستگاه عصبی مرکزیBreast cancer - سرطان پستانcentral nervous system - سیستم عصبی مرکزیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیLinkage disequilibrium - عدم تعادل پیوستگیconfidence interval - فاصله اطمینانminor allele frequency - فراوانی آللی جزئیGrowth mixture modeling - مدل سازی مخلوط رشدBayesian information criterion - معیار اطلاعات بیزیodds ratio - نسبت شانس هاAncestry informative markers - نشانگرهای رسمی اجدادیKarnofsky performance status - وضعیت کارنوفسکیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدCytokine genes - ژن های سیتوکین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Association between an interleukin 1 receptor, type I promoter polymorphism and self-reported attentional function in women with breast cancer Association between an interleukin 1 receptor, type I promoter polymorphism and self-reported attentional function in women with breast cancer](/preview/png/5897692.png)
چکیده انگلیسی
Subgroups of patients with breast cancer may be at greater risk for cytokine-induced changes in cognitive function after diagnosis and during treatment. The purposes of this study were to identify subgroups of patients with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) predictors of subgroup membership. Self-reported attentional function was evaluated in 397 patients with breast cancer using the Attentional Function Index before surgery and for six months after surgery (i.e., seven time points). Using growth mixture modeling, three attentional function latent classes were identified: High (41.6%), Moderate (25.4%), and Low-moderate (33.0%). Patients in the Low-moderate class were significantly younger than those in the High class, with more comorbidities and lower functional status than the other two classes. No differences were found among the classes in years of education, race/ethnicity, or other clinical characteristics. DNA was recovered from 302 patients' samples. Eighty-two single nucleotide polymorphisms among 15 candidate genes were included in the genetic association analyses. After controlling for age, comorbidities, functional status, and population stratification due to race/ethnicity, IL1R1 rs949963 remained a significant genotypic predictor of class membership in the multivariable model. Carrying the rare “A” allele (i.e., GA + AA) was associated with a twofold increase in the odds of belonging to a lower attentional function class (OR: 1.98; 95% CI: 1.18, 3.30; p = .009). Findings provide evidence of subgroups of women with breast cancer who report distinct trajectories of attentional function and of a genetic association between subgroup membership and an IL1R1 promoter polymorphism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 65, Issue 2, February 2014, Pages 192-201
Journal: Cytokine - Volume 65, Issue 2, February 2014, Pages 192-201
نویسندگان
John D. Merriman, Bradley E. Aouizerat, Janine K. Cataldo, Laura Dunn, Bruce A. Cooper, Claudia West, Steven M. Paul, Christina R. Baggott, Anand Dhruva, Kord Kober, Dale J. Langford, Heather Leutwyler, Christine S. Ritchie, Gary Abrams, Marylin Dodd,