کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5899260 1155591 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of obesity and gestational diabetes mellitus on placental phospholipids
ترجمه فارسی عنوان
اثرات چاقی و دیابت بارداری بر روی فسفولیپید های جفت
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


- Gestational diabetes and obesity alter placental glycerophospholipids.
- Placental PC(16:0/20:4) was identified as a source of arachidonic acid for the foetus.
- Placental phosphatidylethanolamine with arachidonic acid is associated with growth.

Gestational diabetes mellitus (GDM) is associated with adverse effects in the offspring. The composition of placental glycerophospholipids (GPL) is known to be altered in GDM and might reflect an aberrant fatty acid transfer across the placenta and thus affect the foetal body composition. The aim of this study was to investigate possible effects of obesity and GDM, respectively, on placental GPL species composition.We investigated molecular species of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS) in term placentas from controls (lean non-diabetic, body-mass-index [BMI] 18-24.9 kg/m2, n = 31), obese non-diabetics (BMI ≥30 kg/m2, n = 17) and lean diabetics (n = 15), using liquid chromatography - triple quadrupole mass spectrometry.PE(16:0/22:6) and PE(18:0/20:4) were increased in GDM and decreased species were PC(18:0/20:3), PC(18:1/20:3) and PS(18:0/18:2). A consistent difference between BMI related changes and changes caused by GDM was not observed. Arachidonic acid percentages of cord blood correlated with placental PC(16:0/20:4), whereas foetal docosahexaenoic acid correlated to placental PE species. Furthermore, a positive correlation of placental weight was found to levels of PE containing arachidonic acid.We demonstrated that obesity and GDM are associated with decreased dihomo-gamma-linolenic acid and increased arachidonic acid and docosahexaenoic acid contents of placental GPL, with unknown consequences for the foetus. PC(16:0/20:4) was identified as the major component for the supply of arachidonic acid to the foetal circulation, whereas PE containing arachidonic acid was found to be associated to the placental and infant growth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 109, Issue 2, August 2015, Pages 364-371
نویسندگان
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