کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5903689 | 1157102 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum ferritin levels predict incident non-alcoholic fatty liver disease in healthy Korean men
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کلمات کلیدی
NAFLDGGTHOMA-IRFBGHDLALThigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازthe homeostasis model assessment of insulin resistance - ارزیابی مدل هوموستازیای مقاومت به انسولینnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیMetabolic syndrome - سندرم متابولیکbody mass index - شاخص توده بدنBMI - شاخص توده بدنیUltrasound - فراصوتfasting blood glucose - قند خون ناشتاLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)METS - متسC reactive protein - پروتئین واکنشی CCRP - پروتئین واکنشی سی یا سی. آر. پی Gamma-glutamyltransferase - گاما گلوتامیل ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Little research has been done to examine the temporal relationship between serum ferritin and the development of nonalcoholic fatty liver disease. The aim of this study was to examine whether serum ferritin levels predict incident fatty liver in non-diabetic men. The study cohort comprised 2410 healthy Korean male who were aged 30 to 59Â years old with no evidence of ultrasonographically detectable fatty liver (USFL) at baseline. Alcohol intake was assessed with a self-reported questionnaire. At each visit, biochemical and anthropometric measurements and abdominal ultrasonography were done. Cox proportional hazard models were used to calculate the adjusted hazard ratios in separate models for USFL. During 7545.9 person-years of follow-up, 586 participants developed USFL. The hazard ratio (95% confidence interval) for incident USFL comparing the highest quartile of serum ferritin level to the lowest quartile was 1.54 (1.21-1.94) after adjusting for age, body mass index, smoking, alcohol intake, and exercise. That association remained significant after further adjustment for cardiovascular risk factors and in time-dependent models. The association between serum ferritin and incident USFL was still significant in the non-overweight group or the no current smoker group. Serum ferritin level was an independent risk factor of incident fatty liver detected by ultrasonography even in non-obese, healthy Korean men. Increased serum ferritin levels appear to be an early predictor for incident fatty liver.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 61, Issue 8, August 2012, Pages 1182-1188
Journal: Metabolism - Volume 61, Issue 8, August 2012, Pages 1182-1188
نویسندگان
Chan-Won Kim, Yoosoo Chang, Eunju Sung, Hocheol Shin, Seungho Ryu,