کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5904343 | 1157978 | 2015 | 7 صفحه PDF | دانلود رایگان |
Dietary nitrate (NO3â) supplementation has been proposed as an emerging treatment strategy for type 2 diabetes. We hypothesized that ingestion of a single bolus of dietary NO3â ingestion improves oral glucose tolerance in patients with type 2 diabetes. Seventeen men with type 2 diabetes (glycated hemoglobin, 7.3% ± 0.2%) participated in a randomized crossover experiment. The subjects ingested a glucose beverage 2.5 hours after consumption of either sodium NO3â (0.15 mmol NaNO3â · kgâ1) or a placebo solution. Venous blood samples were collected before ingestion of the glucose beverage and every 30 minutes thereafter during a 2-hour period to assess postprandial plasma glucose and insulin concentrations. The results show that plasma NO3â and nitrite levels were increased after NaNO3â as opposed to placebo ingestion (treatment-effect, P = .001). Despite the elevated plasma NO3â and nitrite levels, ingestion of NaNO3â did not attenuate the postprandial rise in plasma glucose and insulin concentrations (time à treatment interaction, P = .41 for glucose, P = .93 for insulin). Despite the lack of effect on oral glucose tolerance, basal plasma glucose concentrations measured 2.5 hours after NaNO3â ingestion were lower when compared with the placebo treatment (7.5 ± 0.4 vs 8.3 ± 0.4 mmol/L, respectively; P = .04). We conclude that ingestion of a single dose of dietary NO3â does not improve subsequent oral glucose tolerance in patients with type 2 diabetes.
Journal: Nutrition Research - Volume 35, Issue 8, August 2015, Pages 674-680