کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5907789 1160871 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The interplay between genome organization and nuclear architecture of primate evolutionary neo-centromeres
ترجمه فارسی عنوان
تعامل بین سازمان ژنوم و معماری هسته ای نووستی های تکاملی پریمات
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی


- We studied chromosomes that differ only by ENC between ancestral/derived species.
- We examined the localization of the ENC in both species by 3D FISH.
- We compared the results with the CT conformation changes caused by an inversion.
- Events as an inversion can cause big changes in the organization of a CT.
- The repositioning of a centromere doesn't affect strongly the organization of a CT.

An Evolutionary Neo-Centromere (ENC) is a centromere that emerged in an ectopic region of a chromosome during evolution. It is thought that the old centromere must be inactivated because dicentric chromosomes are not viable. The aim of the present study was to investigate whether 3D arrangement in the interphase nucleus of the novel and old centromeric domains was affected by the repositioning event. The data we present here strongly indicate that the ENC phenomenon does not affect the 3D location of either novel or old centromeres. Very likely, other features, such as gene density, rather than the newly acquired or lost functions, define positioning in the nucleus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 102, Issue 4, October 2013, Pages 288-295
نویسندگان
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