کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5907873 1160876 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prevalence and mapping of a plasmid encoding a type IV secretion system in Acinetobacter baumannii
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Prevalence and mapping of a plasmid encoding a type IV secretion system in Acinetobacter baumannii
چکیده انگلیسی


- We investigated the prevalence of a T4SS-bearing plasmid among Acinetobacter baumannii.
- Fourteen out of seventeen T4SS genes are highly conserved in seven representative plasmids.
- The T4SS lineages may be evolutionarily distinct from their chromosome.
- T4SS-bearing plasmids are widespread in A. baumannii strains.

We investigated the prevalence of a type IV secretion system (T4SS)-bearing plasmid among clinical isolates of carbapenem-resistant Acinetobacter baumannii (CRAB) using plasmid replicon typing. The complete sequence of a T4SS-bearing plasmid, pAB_CC, isolated from A. baumannii TYTH-1 was determined, and a comparative analysis of the T4SS gene modules was performed. Of the 129 isolates studied, GR6 (repAci6) was the most common (45 of 96 isolates) and was strongly linked with the T4SS. A comparative analysis of the T4SS locus in seven plasmid genomes, including pAB_CC, pACICU2, pABKp1, pABTJ1, p1BJAB0714, p2BJAB0868, and p2ABTCDC0715, indicated that fourteen genes on these plasmids were highly conserved compared to those of the F plasmid. Additionally, the chromosomes in the seven representative isolates may be evolutionarily distinct from their intrinsic T4SS-bearing plasmids, suggesting that the two T4SS lineages emerged long before the appearance of EC II. These two lineages are now widespread in A. baumannii strains.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 104, Issue 3, September 2014, Pages 215-223
نویسندگان
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