Deleterious effects of indomethacin in the mid-gestation human intestine

► The effects of a low dose of indomethacin on the intact human intestine were tested. ► Indomethacin modulates pathways other than only those that are inflammation-related. ► Glycolysis and oxidative stress are among the main indomethacin targets in the gut. ► This clarifies the deleterious effects of indomethacin on neonatal gut pathologies.