کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5912250 | 1161434 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Managing flushing and gastrointestinal events associated with delayed-release dimethyl fumarate: Experiences of an international panel
ترجمه فارسی عنوان
مدیریت حوادث وحشی و گوارشی مرتبط با دیمتیل فومارات آزاد شده با تاخیر انتشار: تجربیات یک پیمان بین المللی
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کلمات کلیدی
مولتیپل اسکلروزیس، تحمل پذیری، دی متیل فومارات، عوارض جانبی، عوارض جانبی گوارشی، فلاشینگ،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
Strategies for monitoring and managing the known adverse event (AE) profile of therapies for relapsing-remitting multiple sclerosis have become key to the optimization of patient outcomes. Delayed-release dimethyl fumarate (DMF) was associated with an increased risk of flushing and gastrointestinal (GI) AEs in clinical trials. A survey of clinicians with significant research experience using delayed-release DMF was conducted to provide guidance to clinicians using delayed-release DMF in clinical practice on the management of flushing and GI tolerability AEs. Recommendations for prophylaxis included educating the patient about flushing and GI AEs associated with delayed-release DMF and recommending administration with food. A variety of symptomatic treatments were utilized during the delayed-release DMF clinical trials in patients presenting with delayed-release DMF-related flushing or GI AEs that were severe or bothersome enough to warrant pharmacological intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Multiple Sclerosis and Related Disorders - Volume 3, Issue 4, July 2014, Pages 513-519
Journal: Multiple Sclerosis and Related Disorders - Volume 3, Issue 4, July 2014, Pages 513-519
نویسندگان
J. Theodore Phillips, Michael Hutchinson, Robert Fox, Ralf Gold, Eva Havrdova,