کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5912336 1570209 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Case reportAnti-N-methyl-d-aspartate receptor encephalitis in a patient with neuromyelitis optica spectrum disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Case reportAnti-N-methyl-d-aspartate receptor encephalitis in a patient with neuromyelitis optica spectrum disorders
چکیده انگلیسی


- This paper describes a Chinese NMOSD patient developed with anti-NMDAR encephalitis.
- Anti-NMDAR antibodies and AQP4-IgG were all positive in serum and CSF of the patient.
- The patient had a good response to reduced dosage of rituximab.

We described a female patient with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis occurring sequentially with neuromyelitis optica spectrum disorders (NMOSD). The 19-year-old patient initially presented a diencephalic syndrome with aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) and brain lesions which involving bilateral medial temporal lobes and periependymal surfaces of the third ventricle on magnetic resonance imaging (MRI). Ten months later, the patient developed cognitive impairment, psychiatric symptoms and dyskinesia with left basal ganglia lesions on brain MRI. Meanwhile, the anti-NMDAR antibodies were positive in the patient's serum and cerebrospinal fluid, while the screening tests for an ovarian teratoma and other tumors were all negative. Hence, the patient was diagnosed NMOSD and anti-NMDAR encephalitis followed by low-dose rituximab treatment with a good response. This case was another evidence for demyelinating syndromes overlapping anti-NMDAR encephalitis in Chinese patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Multiple Sclerosis and Related Disorders - Volume 8, July 2016, Pages 74-77
نویسندگان
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