کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5912677 1161443 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Burden of multiple sclerosis on direct, indirect costs and quality of life: National US estimates
ترجمه فارسی عنوان
بار مولتیپل اسکلروز در هزینه های مستقیم، غیر مستقیم و کیفیت زندگی: تخمین های ملی ایالات متحده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی


- US multiple sclerosis (MS) prevalence was 572,312 (95% CI: 397,004, 747,619).
- Annual direct costs were $24,327 higher for the MS population (n=526).
- MS patients lost on average 10.04 quality-adjusted life years vs. non-MS cohort.
- MS was associated with higher direct and indirect costs and lower HRQoL.

BackgroundMS imposes a significant burden on patients, caregivers, employers, and the healthcare system.ObjectiveTo comprehensively evaluate the US MS burden using nationally representative data from the Medical Expenditure Panel Survey.MethodsWe identified non-institutionalized patients aged ≥18 with MS (ICD-9 code 340) from 1998 to 2009 and compared them to individuals without an MS diagnosis (non-MS) during the interview year. The cohorts were compared using multivariate regression on direct costs, indirect costs (measured in terms of employment status, annual wages, and workdays missed), and health-related quality of life (HRQoL; measured using Short Form 12, SF-6 Dimensions, and quality-adjusted life years [QALYs]).ResultsMS prevalence was 572,312 (95% CI: 397,004, 747,619). Annual direct costs were $24,327 higher for the MS population (n=526) vs. the non-MS population (n=270,345) (95% CI: $22,320, $26,333). MS patients had an adjusted 3.3-fold (95% CI: 2.4, 4.5) increase in the odds of not being employed vs. non-MS individuals and a 4.4-fold higher adjusted number of days in bed (95% CI 2.97, 6.45). On average, MS patients lost 10.04 QALYs vs. non-MS cohort.ConclusionsMS was associated with higher healthcare costs across all components, reduced productivity due to unemployment and days spent in bed, and lower HRQoL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Multiple Sclerosis and Related Disorders - Volume 3, Issue 2, March 2014, Pages 227-236
نویسندگان
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