کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
592355 1453902 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Generation of alginate nanoparticles through microfluidics-aided polyelectrolyte complexation
ترجمه فارسی عنوان
تولید نانوذرات آلژینات از طریق ترکیب پلی اتیلن الکترولیتی با کمک میکروفلدیک
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• Alginate nanoparticles were generated by polyelectrolyte complexation between alginate and poly-l-lysine (PLL) through a microfluidic mixing device.
• The alginate nanoparticles generated by microfluidic mixing exhibited enhanced aggregation stability, when compared with those obtained with the conventional bulk mixing method.
• Through tuning of the flow rates in the microfluidic device, the size of alginate nanoparticles was controlled.

Alginate-based nanoparticles were generated by mixing two types of stock solutions through a microfluidic device. In our microfluidic mixing device, aqueous Ca-alginate pre-gels and cationic poly-l-lysine (PLL) solutions were mixed, and the polyelectrolyte complexation that subsequently occurred between the pre-gel and PLL resulted in precipitates, yielding alginate nanoparticles. Due to the faster microfluidic mixing achieved compared with that obtained with the conventional bulk mixing method, the alginate nanoparticles exhibited enhanced aggregation stability. The control of the size of the nanoparticles through the tuning of the flow rates in the microfluidic device was also achieved.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 471, 20 April 2015, Pages 86–92
نویسندگان
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