کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
592599 1453912 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formulation and characterization of Tween 80/cholestherol niosomes modified with tri-n-octylmethylammonium chloride (TOMAC) for carboxylic acids entrapment
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Formulation and characterization of Tween 80/cholestherol niosomes modified with tri-n-octylmethylammonium chloride (TOMAC) for carboxylic acids entrapment
چکیده انگلیسی


• TOMAC increased the degree of Tween 80 aggregation and decreased the niosome size.
• TOMAC is adsorbed at the surface and gives positive charge to the niosomes.
• Citric acid entrapment efficiency increased with the presence of TOMAC.
• Lactic acid entrapment was hardly affected by the presence of TOMAC.
• Carboxylic acid entrapment was explained in terms of interaction with the niosomes.

The effects of different formulations on the physicochemical properties of unloaded and carboxylic acid-loaded niosomes are studied. Citric acid and lactic acid were the model carboxylic acids employed. The niosomes were prepared by ultrasonication of different formulations in a phosphate buffer at pH 2 and 7 containing Tween 80 (polyoxyethylene (20) sorbitan monooleate) and cholesterol as the vesicle forming agents. This study examines the effect of tri-n-octylmethylammonium chloride (TOMAC) on the degree of Tween 80 aggregation, acid entrapment efficiency, hydrodynamic size, and zeta potential of the formulated niosomes. Carboxylic acid entrapment efficiency may be explained in terms of interaction within the solubilization sites of the niosomes. TOMAC addition at pH 7 increased both the Tween 80 aggregation and citric acid entrapment efficiencies, but its effect on lactic acid entrapment was lower.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 461, 5 November 2014, Pages 167–177
نویسندگان
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