Pluronic-cationic surfactant mixed micelles: Solubilization and release of the drug hydrochlorothiazide

- Aqueous mixed systems of Pluronics® with cationic surfactants were studied.
- Pluronic®-surfactant systems were found to be more efficient for HCT loading.
- Drug release rates can be tune by the addition of varying amounts of cationic surfactant.
- Different kinetic models are used to explain the in vitro drug release profile.