کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
594333 | 1453980 | 2012 | 6 صفحه PDF | دانلود رایگان |

Two series of long chain guanidine surfactants, mono-alkylguanidine and N,N,N′-dimethylalkylguanidine were synthesized and the effect of the alkyl chain length and the nature of the cationic headgroup on aggregation and antimicrobial activity were investigated. Surface tension and conductivity were applied to study the aggregation of the amphiphilic molecules in aqueous solution. The antimicrobial activity was evaluated against Gram-negative, Gram-positive bacteria and fungi. The results showed that N,N,N′-dimethylalkylguanidine had much higher surface activity than those of mono-alkylguanidine with the hydrophobicity of the amphiphilic cation. Guanidine surfactants containing 8–12 carbon atoms in the alkyl chain showed antimicrobial activity at the concentration of 25–100 ppm, and their efficiency as antimicrobial agents increased with the chain length.
Figure optionsDownload as PowerPoint slideHighlights
► Two series of guanidine surfactants were synthesized and characterized.
► Guanidine surfactants had high surface activities.
► Increase in alkyl chain resulted in an increase in antimicrobial activity.
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 393, 5 January 2012, Pages 11–16