کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5943381 1574718 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Smoking is associated with lower amounts of arterial type I collagen and decorin
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Smoking is associated with lower amounts of arterial type I collagen and decorin
چکیده انگلیسی


- Smoking is associated with less collagen and decorin in the arterial wall.
- Proteome analysis and histomorphometric analysis showed similar results.
- This may contribute to altered arterial remodelling and formation of aneurysms.

BackgroundSmoking affects the arterial wall and increases the risk of cardiovascular disease. It also affects the extracellular matrix in skin, causing impaired wound healing. However, little is known about putative molecular changes in the arterial wall. Our aim was to investigate the possible correlation between extracellular matrix content in arterial tissue and cigarette smoking.MethodsWe studied the non-atherosclerotic arterial wall of the internal mammary artery from coronary artery by-pass surgery in 13 never-smokers and 11 active smokers. Using histomorphometric methods, the area fraction of collagen stainable material was determined. In addition, proteome analysis of matrix molecules and other proteins was performed.ResultsThe area fraction of collagen stainable material in smokers vs. never-smokers was 29.1% ± 3.8% vs. 43.3% ± 3.6% (mean ± SEM, p = 0.012) in tunica intima, 39.7% ± 5.5% vs. 56.8% ± 5.6% (mean ± SEM, p = 0.042) in tunica media, and 50.4% ± 3.9% vs. 61.0% ± 3.2% (mean ± SEM, p = 0.046) in tunica adventitia.We discovered significantly lower relative levels of collagen α1(I) (0.68 ± 0.048 vs. 1.02 ± 0.112, mean ± SEM, p = 0.013), collagen α2(I) (0.81 ± 0.046 vs. 1.14 ± 0.118, mean ± SEM, p = 0.038) and decorin (0.64 ± 0.04 vs. 0.98 ± 0.11, mean ± SEM, p = 0.009) in smokers.ConclusionsArterial tissue from active smokers contains decreased amounts of collagen stainable material, as well as type 1 collagen and decorin. These findings may explain some effects of smoking on the development of cardiovascular disease including compromised remodelling and increased risk of aneurysms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 247, April 2016, Pages 201-206
نویسندگان
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