Effects of a cosurfactant on the shear-dependent structures of systems composed of biocompatible ingredients

The phase transitions of systems composed of water, polyoxyethylene sorbitan monooleate (Tween 80), medium-chain triglycerides (MCTs) and ethanol were evaluated based on rheological properties using different proportions of MCT:ethanol (1:0, 2:1 and 1:2). Higher ethanol contents led to a broadened microemulsion (ME) region and a diminished liquid crystalline (LC) region in the phase diagram and resulted in the formation of systems with smaller particle sizes, lower viscosities and less shear-thinning. Different systems were obtained from the water titration of an initial mixture of 70% (w/w) surfactant and 30% (w/w) oil + ethanol. At low water contents, Newtonian W/O MEs were produced. At intermediate water contents, LC phases were observed, including viscous and gel-like structures with viscoelastic properties and complex rheology (shear-thinning, Bingham plastic or Herschel–Buckley behaviour). In addition, these samples exhibited time-dependent behaviours, showing thixotropy in systems rich in amphiphilic and nonpolar components and anti-thixotropy in systems with a prevalence of polar (ethanol and water) components. According to oscillatory measurements, cubic phases were most likely formed at 40% (w/w) water in systems with low (or an absence of) ethanol. At higher water contents (>50%, w/w), O/W milk-like emulsions were produced in systems with low ethanol contents, whereas O/W MEs were produced in the system with a high ethanol content. O/W MEs exhibited larger droplet sizes and lower viscosities than W/O MEs. The different structures depended strongly on the system composition, which enables the production of textures with potential applications in the food, cosmetic and pharmaceutical industries.

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► Structural changes were effectively identified by different rheological techniques.
► Ethanol increased microemulsion region and produced systems less shear-thinning and structured.
► Liquid crystalline phase showed complex rheology under small and high deformation.
► Thixotropic behaviour was observed in systems with prevailing nonpolar or amphiphilic components.
► Systems rich in polar components (water and ethanol) showed anti-thixotropic behaviour.