کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
594370 879449 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel nano-porous hydrogel as a carrier matrix for oral delivery of tetracycline hydrochloride
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Novel nano-porous hydrogel as a carrier matrix for oral delivery of tetracycline hydrochloride
چکیده انگلیسی

A novel nano-porous hydrogel (NPH) was synthesized via graft copolymerization of sodium acrylate (Na-AA) and acrylamide (AAm) onto salep backbones and its application as a carrier matrix for oral delivery of tetracycline hydrochloride (TH) was investigated. The Taguchi method as a strong experimental design tool was used for synthesis optimization. The swelling behavior of optimum hydrogel was measured in various media. The hydrogel formation was confirmed by Fourier transform infrared spectroscopy (FT-IR) and thermogravimetrical analysis (TGA). The study of the surface morphology of the hydrogels using SEM and AFM showed a nanoporous (average pore size: 180 nm) structure for the sample obtained under optimized conditions. The drug delivery results demonstrated that this NPH could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be a good candidate as an orally administrated drug delivery system.

Figure optionsDownload as PowerPoint slideHighlights
► We synthesize a novel nano-porous hydrogel.
► We graft sodium acrylate and acrylamide onto salep biopolymer.
► We use the hydrogel as a carrier matrix for delivery of tetracycline hydrochloride.
► We use the Taguchi method for synthesis optimization.
► The SEM and AFM show a nano-porous structure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 392, Issue 1, 5 December 2011, Pages 16–24
نویسندگان
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